Enhancing the co-evolution signal in thousands of species (Phylogenetic profiling)

Phylogenetic profiling optimization Phylogenetic profiling is a method for elucidation of gene function based on similarities in evolutionary histories between genes.

We study how to optimize the signal to better identify functional interaction between genes.

We built the CladeOScope web tool to enable all researchers look at co-evolved genes in multiple clades. We also used machine learning to improve the PP signal.