Controlling aging

Ablation of the AGE-1 gene in c. elegans nematodes causes remarkable extension in lifespan.

We investigate AGE-1 gene network, using comparative genomics and data integration, to reveal novel interactors of age-1.

Our working hypothesis is that the AGE-1-interacting network presents a promising opportunity for therapeutic intervention to counter proteotoxicity, which is mechanistically linked to aging.

We plan to test the functional relevance of our identified genes using proteotoxicity model nematodes.